Gaman ga Dekinai Doutei Aniki to Sunao ni Narenai Hankou Imouto
Gaman ga Dekinai Doutei Aniki to Sunao ni Narenai Hankou Imouto - Sister Position
The older brother of four younger sisters - the protagonist - had severe asthma when he was younger. Due to this, they started the routine of one of the sisters sleeping with him for one day and then switching to another.
One day, their parents, who are researchers, ordered a demonstration of their newest experiment, "Improve his immunity by hugging him."
"Hug a little sister affectionately for 10 seconds every day before going to bed♪"
He decided to hug the sister he was going to sleep with him with even more affection then she could ever imagine...